Constitutive Knock Out

Permanently inactivates a target gene in all cells of the body throughout development.

Conditional Knock Out

Eliminates gene function in a tissue-specific manner when combined with the appropriate Cre expressing mouse line.

Constitutive KO with the option for conditional KO

The model allows the flexibility to generate both the constitutive KO and the conditional KO from the same gene targeting event.

Tamoxifen inducible KO

Inactivates gene expression in an inducible manner at any stage of mouse development utilizing a tamoxifen incudible Cre-ER technology.