Thyroid disease models

  • Thyroid-specific Gq/11 deficient mice.

These mice are lacking the Gq/11- mediated signalling pathway in the thyroid after the thyroglobulin promoter activates at E15-17. It leads to slowly progressing hypothyroidism. The thyrocytes have reduced ablity to organificate iodine and secrete thyroid hormones in response to TSH. In addition, thyrocyte-specific Gq/G11-deficient mice lacked the normal proliferative thyroid response to TSH or goitrogenic diet, indicating an essential role of this pathway in the adaptive growth of the thyroid gland. (Kero J et al. JCI 2007)

Contact
Jukka Kero MD,PhD
Email: jukka.kero(at)utu.fi
Screen Shot 2014-03-06 at 11.19.57(Kero J et al. JCI 2007)
Models for thyroid diseases

  • Thyroid specific  G12/13 deficient mice.

We have generated mice lacking alpha subunits of G12 and 13 G-proteins in thyroid ephitelial cells. We are currently evaluating the role of G12/13 signalling in the thyroid development and adult thyroid physiology.

Contact
Jukka Kero MD,PhD
Email: jukka.kero(at)utu.fi
 Screen Shot 2014-03-06 at 13.26.59
Models for thyroid diseases
  • Thyroid specific DICER1 KO mice. 

MicroRNAs play important role in thyroid cancer and development.To understand the role of Dicer1 in thyroid in vivo, we have generated a constitutive, thyrocyte-specific Dicer1 knockout mouse line (cTgKO) by crossing Dicer1 fl/fl mice with Tg-Cre mice expressing the Cre recombinase under the thyroglobulin promoter. Additionally, we have created an inducible thyrocyte-specific Dicer1 KO model (iTgKO) by using a mouse line expressing a tamoxifen-inducible Cre under the thyroglobulin promoter to be able to study the role of Dicer1 in adult thyroid. We are currently evaluating these models.

Contact
Jukka Kero MD,PhD
Email: jukka.kero(at)utu.fi
 Screen Shot 2014-03-06 at 13.18.47
Models for thyroid diseases