Biostatistical Analyses
Huhtaniemi R, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala TD, Nicorici D, Aittokallio T, Laiho A, Elo L, Ohlsson C, Kallio P, Mäkelä S, Mustonen MVJ, Sipilä P, Poutanen M. Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts. Am J Pathol. 2018 Dec;188(12):2890-2901.
https://www.ncbi.nlm.nih.gov/pubmed/30273606
Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M. Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts.Am J Pathol. 2018 Jan;188(1):216-228
https://www.ncbi.nlm.nih.gov/pubmed/29126837
Cardiovascular Analyses
Rinne P, Ahola-Olli A, Nuutinen S, Koskinen E, Eerola K, Juonala M, Kähönen M, Lehtimäki T, Raitakari OT, Savontaus E. Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans. Arterioscler Thromb Vasc Biol 2015 Apr 30. pii: ATVBAHA.114.305064
http://www.ncbi.nlm.nih.gov/pubmed/25931512
Anttila K, Streng T, Pispa J, Vainio M, Nikinmaa M. Hypoxia exposure and B-type natriuretic peptide release from Langendorff heart of rats. Acta Physiol (Oxf). 2017 May;220(1):28-35.
https://www.ncbi.nlm.nih.gov/pubmed/27496203
Nuutinen S, Ailanen L, Savontaus E, Rinne P. Melanocortin overexpression limits diet-induced inflammation and atherosclerosis in LDLR-/- mice. J Endocrinol. 2018 Mar;236(3):111-123. doi: 10.1530/JOE-17-0636. Epub 2018 Jan 9.
https://www.ncbi.nlm.nih.gov/pubmed/29317531
Intestinal diseases
Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor SK, Stenvall CA, Fortelius LE, Bergström LK, Sahlgren C, Toivola DM. Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway. Cell Death Differ. 2017 Jun;24(6):984-996.
https://www.ncbi.nlm.nih.gov/pubmed/28475172
Nutrition and Metabolism Analyses
Ailanen L, Ruohonen ST, Vähätalo LH, Tuomainen K, Eerola K, Salomäki-Myftari H, Röyttä M, Laiho A, Ahotupa M, Gylling H, Savontaus E. The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons. J Endocrinol. 2017 Jul;234(1):57-72. https://www.ncbi.nlm.nih.gov/pubmed/28468933
Ali I, Hurmerinta T, Nurmi T, Berglund M, Rüegg J, Poutanen M, Halldin K, Mäkelä S, Damdimopoulou P. From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo. Toxicol Lett. Jun 24;253:27-35, 2016
http://www.ncbi.nlm.nih.gov/pubmed/27108949
Vähätalo L, Ruohonen ST, Kovalainen M, Huotari H, Mäkelä K, Määttä JA, Mäkelä S, Ailanen S, Ruohonen S, Röyttä M, Herzig KH, Savontaus E. Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone. Acta Physiol (Oxf). 213:902-19, 2015 https://www.ncbi.nlm.nih.gov/pubmed/25482272
Ruohonen S, Valve L, Tuomainen K, Ailanen L, Röyttä M, Manz G, Baur N, Joos T, Savontaus E, Scheinin M. Increased energy expenditure, lipolysis, and hyperinsulinemia confer resistance to central obesity and type 2 diabetes in mice lacking alpha2A-adrenoceptors. Neuroendocrinology. 2018 107(4):324-339. https://www.ncbi.nlm.nih.gov/pubmed/30041171
PET Imaging
O’Farrell AC, Evans R, Silvola JM, Miller IS, Conroy E, Hector S, Cary M, Murray DW, Jarzabek MA, Maratha A, Alamanou M, Udupi GM, Shiels L, Pallaud C, Saraste A, Liljenbäck H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Arany Z, Ky B, Force T, Knuuti J, Gallagher WM, Roivainen A, Byrne AT. A novel positron emission tomography (PET) approach to monitor cardiac metabolic pathway remodeling in response to sunitinib malate. PLoS One 12:e0169964, 2017
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169964
Stapel B Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JMU, Roivainen A, Saraste A, Nickel AG, Saar JA, Gorst I, Pietzsch S, Müller M, Jauhiainen M, Thackeray J, Scherr M Bengel F, Bauersachs J, Maack C, Hilfiker-Kleiner D. Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy. Eur Heart J 38:349-361, 2017
https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehw086
Reproductive Analyses
Ruohonen ST, Gaytan F, Usseglio Gaudi A, Velasco I, Kukoricza K, Perdices-Lopez C, Franssen D, Guler I, Mehmood A, Elo LL, Ohlsson C, Poutanen M, Tena-Sempere M. Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure. Hum Reprod. 2022 Apr 1;37(4):806-821.
https://pubmed.ncbi.nlm.nih.gov/35037941/
Zhang F-P, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Korhonen H, Laiho A, Elo L, Ohlsson C, Kotaja N, Poutanen M, Sipilä P, Palvimo J. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction. Nature Communications 2019 Feb 15;10(1):777
https://www.ncbi.nlm.nih.gov/pubmed/30770815