Hypertension – induced models
Diet high in NaCl content (high-salt diet) is used to induce hypertension in mice. DOCA-salt induced hypertension combines deoxycorticosterone acetate and high salt intake to induce high blood pressure. References: Rinne P et al α-MSH Analogue Attenuates Blood Pressure Elevation in DOCA-Salt Hypertensive Mice. PLoS One 8(8):e72857, 2013. |
Contact Petteri Rinne, PhD, pperin(at)utu.fi |
High-salt induced hypertension in mice | |
Impaired vascular function
Diets high in fat (diet induced obesity) or salt (diet induced hypertension) impair endothelial function, which is evidenced using vascular function analysis by wire myography. Reference: |
Contact Petteri Rinne, PhD, pperin(at)utu.fi |
Endothelial dysfunction – the first sign of vascular disease | |