Hsd17b2 knock-out mouse model

Hsd17b2 knock-out mouse model. HSD17B2 is known to catalyze the inactivation of 17ß-hydroxysteroids to less active 17-keto forms, and catalyze the conversion of 20α-hydroxyprogesterone to progesterone in vitro. Homozygous mice carrying the disrupted Hsd17b2 gene present embryonic lethality associated with structural abnormalities in placenta. Contact Professor Matti Poutanen, matti.poutanen(at)utu.fi
Detailed information: Rantakari et al., Mol Endocrinol. 2008 Mar;22(3):665-75

Brca2 flox mouse line

Mouse line, where Brca2 exon 11 is floxed. Combined with tissue-specific Cre mouse line creates conditional deletion of Brca2. Brca2 is a tumor suppressor gene whose mutations predispose to different type of cancers. Original article: Jonkers et al., Nature Genetics  29:418 – 425, 2001   

Nina Messner