Academy lecturer Diana Toivola, Åbo Akademi University, Faculty of Science and Engineering/Department of Cell Biology, was awarded a prestigious 3-year grant of 3 million DKK from the Novo Nordisk foundation, committee on endocrinology and metabolism, which supports biomedical research in all Nordic countries.
The aim of the basic science research is to find new molecular mechanisms important for beta cell health in the endocrine pancreas. Beta cells are vital to the body by producing the hormone insulin, which is required for the absorption of nutrients in the form of glucose to tissues. When blood glucose levels rise, for example after a meal, beta cells are stimulated to produce insulin. In patients with diabetes mellitus, a disease with a very high prevalence in Finland, beta cells are destroyed, leading to a decreased insulin production and uncontrolled blood glucose levels. In this research project, the research group will investigate how stress-protective proteins, keratins, maintain beta-cell health with special focus on glucose-stimulated production, transport and secretion of insulin.
Petteri Rinne started as a coordinator of Cardiovascular research unit. He did his PhD at the Department of Pharmacology, Drug Development and Therapeutics in 2013. After doing postdoctoral research in Munich, Germany, he has returned to Turku and is currently working as a postdoctoral researcher in the Turku Collegium for Science and Medicine. His current research projects focus on the role of melanocortin and endocannabinoid signalling in cardiovascular diseases. In particular, the research aims at evaluating the therapeutic potential of targeting these systems for the management of atherosclerosis and heart failure.
The authors (Aittokallio, Scherer, Poutanen, Freedman) within the article (http://stm.sciencemag.org/content/9/389/eaal4101.short ) emphasize the importance of applying better baseline stratification factors during the preclinical studies to improve the fitness and quality of the models and their translatability to clinical trials. Tools for improving the analyses have also been recently developed by TCDM (https://biomedportal.utu.fi/utu-apps/Rvivo/ ), and scientists are encouraged to apply these tools to further improve the quality of their studies.
At TCDM we are continuously searching solutions for the problems faced by endometriosis patients, physicians and researchers. We are searching for new treatment strategies, aims to improve diagnostics and developing new preclinical models for the disease, e.g. by using patient derived cell lines. Active research over 10 years have resulted in more than 10 scientific publications.
11th Disease Modeling symposium, Cancer and Metabolism, was organized December 13 -14, 2016. The symposium focused on specific aspects of studying cancer and metabolism.
The Director of the TCDM, Matti Poutanen, and the Coordinator/PI of Intestinal Diseases Unit, Diana Toivola, renewed their Endocrinological Research Grants from Novo Nordisk Foundation. Congratulations!
FLIR T620 Infrared Camera has been purchased by the Institute of Biomedicine, the University of Turku. The camera is suitable for thermal imaging of experimental animals, and allows measuring eg. brown adipose tissue temperature in awake, freely moving animals. The camera and imaging service is available in Nutrition and Metabolism Unit.
CASA – computer assisted sperm analyzer, CEROS II from Hamilton Thorne has been purchased by the Institute of Biomedicine at the University of Turku. Detailed sperm analysis include: sperm counts and concentrations, motility, velocity and kinematic measures. Analyses are now available in Reproductive Biology Unit.
TCDM has generated the first knock-out mouse models using CRISPR-Cas9 technology. Service is now available for generation of genetically modified mouse models. See more from our web pages.
The Institute of Biomedicine at the University of Turku has purchased a Faxitron MultiRad 350 irradiator, for biological material. The instrument is a fully-shielded, self-contained X-ray irradiator which is a safer alternative to radioisotope irradiators. The device is the first of its kind in Nordic countries, and it will be used for irradiating various biological materials such as cells and small experimental animals.
The Director of the TCDM, Matti Poutanen, and the Coordinator/PI of Intestinal Diseases Unit, Diana Toivola, were granted by Novo Nordisk Foundation from Endocrinological Research Grants. Congratulations!