Biostatistical Analyses
Huhtaniemi R, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala TD, Nicorici D, Aittokallio T, Laiho A, Elo L, Ohlsson C, Kallio P, Mäkelä S, Mustonen MVJ, Sipilä P, Poutanen M. Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts. Am J Pathol. 2018 Dec;188(12):2890-2901.
https://www.ncbi.nlm.nih.gov/pubmed/30273606
Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M. Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts.Am J Pathol. 2018 Jan;188(1):216-228
https://www.ncbi.nlm.nih.gov/pubmed/29126837
Cardiovascular Analyses
Suominen A, Saldo Rubio G, Ruohonen S, Szabó Z, Pohjolainen L, Ghimire B, Ruohonen ST, Saukkonen K, Ijas J, Skarp S, Kaikkonen L, Cai M, Wardlaw SL, Ruskoaho H, Talman V, Savontaus E, Kerkelä R, Rinne P. α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor. EMBO Rep. 2024 Apr;25(4):1987-2014.
https://pubmed.ncbi.nlm.nih.gov/38454158/
Thapa K, Kadiri JJ, Saukkonen K, Pennanen I, Ghimire B, Cai M, Savontaus E, Rinne P. Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver. Elife. 2023 Jul 25;12:e84782.
https://pubmed.ncbi.nlm.nih.gov/37490042/
Nuutinen S, Ailanen L, Savontaus E, Rinne P. Melanocortin overexpression limits diet-induced inflammation and atherosclerosis in LDLR-/- mice. J Endocrinol. 2018 Mar;236(3):111-123. doi: 10.1530/JOE-17-0636. Epub 2018 Jan 9.
https://www.ncbi.nlm.nih.gov/pubmed/29317531
Digital mouse pathology
Strauss L, Junnila A, Wärri A, Manti M, Jiang Y, Löyttyniemi E, Stener-Victorin E, Lagerquist MK, Kukoricza K, Heinosalo T, Blom S, Poutanen M. Consistent and effective method to define the mouse estrous cycle stage by deep learning based model. J Endocrinol. 2024. 261(3). doi: 10.1530/JOE-23-0204.
Consistent and effective method to define the mouse estrous cycle stage by a deep learning-based model – PubMed (nih.gov)
Mairinoja L, Heikelä H, Blom S, Kumar , Knuuttila A, Boyd S, Sjöblom N, Birkman E-M, Rinne P, Ruusuvuori P, Strauss L, Poutanen M. Deep Learning-Based Image Analysis of Liver Steatosis in Mouse Models. Am J Pathol 2023, 193: 1072-1080. doi: 10.1016/j.ajpath.2023.04.014.
Deep Learning-Based Image Analysis of Liver Steatosis in Mouse Models – PubMed (nih.gov)
Intestinal diseases
Ilomäki MA, Polari L, Stenvall C-GA, Tayyab M, Kähärä K, Ridge KM, Toivola DM. Defining a timeline of colon pathologies after keratin 8 loss: rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation. Am. J. Physiol., Gastroenterol. Liver Physiol. 2024, 326:G67-G77.
https://www.ncbi.nlm.nih.gov/pubmed/28475172
Stenvall C-G, Nyström JH, Butler-Hallissey C, Adam SA, Foisner R, Ridge KM, Gold-man RD, Toivola DM. Keratins Couple With The Nuclear Lamina And Regulate Pro-liferation In Colonic Epithelial cells. Mol. Biol. Cell. 2022, 33 (13): ar121.
https://www.molbiolcell.org/doi/10.1091/mbc.E20-06-0387
Stenvall C-GA, Tayyab M, Grönroos TJ, Ilomäki MA, Viiri K, Ridge KM, Polari L, Toivola DM. Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon. Cell. Mol. Life. Sci. 2022, 79 (1): 10.
Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon – PubMed (nih.gov)
Nutrition and Metabolism Analyses
Ailanen L, Ruohonen ST, Vähätalo LH, Tuomainen K, Eerola K, Salomäki-Myftari H, Röyttä M, Laiho A, Ahotupa M, Gylling H, Savontaus E. The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons. J Endocrinol. 2017 Jul;234(1):57-72. https://www.ncbi.nlm.nih.gov/pubmed/28468933
Ali I, Hurmerinta T, Nurmi T, Berglund M, Rüegg J, Poutanen M, Halldin K, Mäkelä S, Damdimopoulou P. From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo. Toxicol Lett. Jun 24;253:27-35, 2016
http://www.ncbi.nlm.nih.gov/pubmed/27108949
Vähätalo L, Ruohonen ST, Kovalainen M, Huotari H, Mäkelä K, Määttä JA, Mäkelä S, Ailanen S, Ruohonen S, Röyttä M, Herzig KH, Savontaus E. Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone. Acta Physiol (Oxf). 213:902-19, 2015 https://www.ncbi.nlm.nih.gov/pubmed/25482272
Ruohonen S, Valve L, Tuomainen K, Ailanen L, Röyttä M, Manz G, Baur N, Joos T, Savontaus E, Scheinin M. Increased energy expenditure, lipolysis, and hyperinsulinemia confer resistance to central obesity and type 2 diabetes in mice lacking alpha2A-adrenoceptors. Neuroendocrinology. 2018 107(4):324-339. https://www.ncbi.nlm.nih.gov/pubmed/30041171
PET Imaging
Andriana P, Fair-Mäkelä R, Liljenbäck H, Kärnä S, Iqbal I, Makrypidi K, Rajander J, Pirmettis I, Li XG, Jalkanen S, Saraste A, Salmi M, Roivainen A. Macrophage mannose receptor CD206 targeting of fluoride-18 labeled mannosylated dextran: A validation study in mice. Eur J Nucl Med Mol Imaging. 2024 Mar 27.
https://pubmed.ncbi.nlm.nih.gov/38532026/
Bhowmik AA, Heikkilä TRH, Polari L, Virta J, Liljenbäck H, Moisio O, Li XG, Viitanen R, Jalkanen S, Koffert J, Toivola DM, Roivainen A. Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [68Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease. Mol Imaging Biol. 2024 Apr;26(2):322-333.
https://pubmed.ncbi.nlm.nih.gov/38110791/
Jahandideh A, Virta J, Li XG, Liljenbäck H, Moisio O, Ponkamo J, Rajala N, Alix M, Lehtonen J, Mäyränpää MI, Salminen TA, Knuuti J, Jalkanen S, Saraste A, Roivainen A. Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis. J Nucl Cardiol. 2023 Dec;30(6):2760-2772.
https://pubmed.ncbi.nlm.nih.gov/37758963/
Miner MWG, Liljenbäck H, Virta J, Kärnä S, Viitanen R, Elo P, Gardberg M, Teuho J, Saipa P, Rajander J, Mansour HMA, Cleveland NA, Low PS, Li XG, Roivainen A. High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities. Front Immunol. 2023 May 18;14:1145473.
https://pubmed.ncbi.nlm.nih.gov/37275898/
Moisio O, Virta J, Yatkin E, Liljenbäck H, Palani S, Viitanen R, Miner MWG, Oikonen V, Tolvanen T, Vugts DJ, Taimen P, Li XG, Hollmén M, Jalkanen S, Roivainen A. Preclinical Evaluation of 89Zr-Desferrioxamine-Bexmarilimab, a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, in a Rabbit Model of Renal Fibrosis. J Nucl Med. 2023 Apr;64(4):555-560.
https://pubmed.ncbi.nlm.nih.gov/36302655/
Sun L, Aarnio R, Herre EA, Kärnä S, Palani S, Virtanen H, Liljenbäck H, Virta J, Honkaniemi A, Oikonen V, Han C, Laurila S, Bucci M, Helin S, Yatkin E, Nummenmaa L, Nuutila P, Tang J, Roivainen A. [11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue. Eur J Nucl Med Mol Imaging. 2023 Jan;50(2):266-274.
https://pubmed.ncbi.nlm.nih.gov/36166079/
Reproductive Analyses
Junnila A, Zhang FP, Martínez Nieto G, Hakkarainen J, Mäkelä JA, Ohlsson C, Sipilä P, Poutanen M. HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse Testis but Not in Adults. Endocrinology. 2024 Apr 29;165(6):bqae056. doi: 10.1210/endocr/bqae056.
HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse Testis but Not in Adults – PubMed (nih.gov)
Ruohonen ST, Gaytan F, Usseglio Gaudi A, Velasco I, Kukoricza K, Perdices-Lopez C, Franssen D, Guler I, Mehmood A, Elo LL, Ohlsson C, Poutanen M, Tena-Sempere M. Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure. Hum Reprod. 2022 Apr 1;37(4):806-821.
https://pubmed.ncbi.nlm.nih.gov/35037941/
Zhang F-P, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Korhonen H, Laiho A, Elo L, Ohlsson C, Kotaja N, Poutanen M, Sipilä P, Palvimo J. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction. Nature Communications 2019 Feb 15;10(1):777
https://www.ncbi.nlm.nih.gov/pubmed/30770815