PET Imaging

O’Farrell AC, Evans R, Silvola JM, Miller IS, Conroy E, Hector S, Cary M, Murray DW, Jarzabek MA, Maratha A, Alamanou M, Udupi GM, Shiels L, Pallaud C, Saraste A, Liljenbäck H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Arany Z, Ky B, Force T, Knuuti J, Gallagher WM, Roivainen A, Byrne AT. A novel positron emission tomography (PET) approach to monitor cardiac metabolic pathway remodeling in response to sunitinib malate. PLoS One 12:e0169964, 2017
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169964

Stapel B Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JMU, Roivainen A, Saraste A, Nickel AG, Saar JA, Gorst I, Pietzsch S, Müller M, Jauhiainen M, Thackeray J, Scherr M Bengel F, Bauersachs J, Maack C, Hilfiker-Kleiner D. Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy. Eur Heart J 38:349-361, 2017
https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehw086

Rinne P, Hellberg S, Kiugel M, Virta J, Li XG, Käkelä M, Helariutta K, Luoto P, Liljenbäck H, Hakovirta H, Gardberg M, Airaksinen AJ, Knuuti J, Saraste A, Roivainen A. Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques. Mol Imaging Biol 18:99-108, 2016
http://www.ncbi.nlm.nih.gov/pubmed/26122428

Jadhav S, Käkelä M, Mäkilä J, Kiugel M, Liljenbäck H, Virta J, Poijärvi-Virta P, Laitala-Leinonen T, Kytö V, Jalkanen S, Saraste A, Roivainen A, Lönnberg H, Virta P. Synthesis and in vivo PET imaging of hyaluronan conjugates of oligonucleotides. Bioconjugate Chem 27:391-403, 2016
http://www.ncbi.nlm.nih.gov/pubmed/26517303

Tarkia M, Stark C, Haavisto M, Kentala R, Vähäsilta T, Savunen T, Strandberg M, Saunavaara V, Tolvanen T, Teräs M, Pietilä M, Nyman L, Duvall E, Saukko P, Levijoki J, Roivainen A, Saraste A, Knuuti J. Effect of levosimendan therapy on myocardial infarct size and left ventricle function after acute coronary occlusion. Heart, 102:465-471, 2016
http://www.ncbi.nlm.nih.gov/pubmed/26762238

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M. USF1 deficiency activates brown adipose tissue and improves cardiometabolic health. Sci Transl Med 8:323ra13, 2016
http://www.ncbi.nlm.nih.gov/pubmed/26819196

Hellberg S, Silvola JMU, Kiugel M, Liljenbäck H, Metsälä O, Viljanen T, Metso J, Jauhiainen M, Saukko P, Nuutila P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A. Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: An imaging study with positron emission tomography tracer 18F-fluoromethylcholine. Cardiovasc Diabetol 15:26, 2016
http://www.ncbi.nlm.nih.gov/pubmed/26852231

Retamal J, Sörensen J, Lubberink M, Suarez-Sipmann F, Batista Borges J, Feinstein R, Jalkanen S, Antoni G, Hedenstierna G, Roivainen A, Larsson A, Velikyan I. Feasibility of 68Ga-labelled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome. Am J Nucl Med Mol Imaging 6:18-31, 2016
http://www.ncbi.nlm.nih.gov/pubmed/27069763

Nikkanen J, Forsström S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamäki J, Roivainen A, Marjamäki P, Liljenbäck H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lönnqvist T, Sajantila A, Isohanni P, Tyynismaa H, Nomura DK, Battersby BJ, Velagapudi V, Carroll CJ, Suomalainen A. Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism. Cell Metab 23:635-648, 2016
http://www.ncbi.nlm.nih.gov/pubmed/26924217

Stapel B Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JMU, Roivainen A, Saraste A, Nickel AG, Saar JA, Gorst I, Pietzsch S, Müller M, Jauhiainen M, Thackeray J, Scherr M Bengel F, Bauersachs J, Maack C, Hilfiker-Kleiner D. Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy. Eur Heart J, in press
http://www.ncbi.nlm.nih.gov/pubmed/27002120

Virtanen H, Autio A, Siitonen R, Liljenbäck H, Saanijoki T, Lankinen P, Mäkilä J, Käkelä M, Teuho J, Savisto N, Jaakkola K, Jalkanen S, Roivainen A. 68Ga-DOTA-Siglec-9 – a new imaging tool to detect synovitis. Arthritis Res Ther 17:308, 2015 
http://www.ncbi.nlm.nih.gov/pubmed/26530096

Tarkia M, Stark C, Haavisto M, , Kentala R, Vähäsilta T, Savunen T, Strandberg M, Hynninen V-V, Saunavaara V, Tolvanen T, Teräs M, Helin S, Pietilä M, Saukko P, Roivainen A, Saraste A, Knuuti J. Cardiac remodeling in a new pig model of chronic heart failure: assessment of left ventricular functional, metabolic and structural changes using PET, CT and echocardiography. J Nucl Cardiol 22:655–665, 2015
http://www.ncbi.nlm.nih.gov/pubmed/25698475

Ahtinen H, Kulkova J, Lindholm L, Eerola E, Hakanen A, Moritz N, Söderström M, Saanijoki T, Jalkanen J, Roivainen A, Aro H. 68Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections. EJNMMI Res 4:45, 2014
http://www.ncbi.nlm.nih.gov/pubmed/25520903

Uotila S, Silvola JM, Saukko P, Nuutila P, Heinonen SE, Ylä-Herttuala S, Roivainen A, Knuuti J, Saraste A. [18F]Fluorodeoxyglucose uptake in atherosclerotic plaques is associated with reduced coronary flow reserve in mice. J Ultras Med 33:1941–1948, 2014
http://www.ncbi.nlm.nih.gov/pubmed/25336481

Rinne P, Silvola JM, Hellberg S, Ståhle M, Liljenbäck H, Salomäki H, Koskinen E, Nuutinen S, Saukko P, Knuuti J, Saraste A, Roivainen A, Savontaus E. Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice. Arterioscler Thromb Vasc Biol 34:1346–1354, 2014
http://www.ncbi.nlm.nih.gov/pubmed/24790139

Kiugel M, Dijkgraaf I, Kytö V, Helin S, Liljenbäck H, Saanijoki T, Yim C-B, Oikonen V, Saukko P, Knuuti J, Roivainen A, Saraste A. Dimeric 68Ga-DOTA-RGD peptide targeting αvβ3 integrin reveals extracellular matrix alterations after myocardial infarction. Mol Imaging Biol 16:793–801, 2014
http://www.ncbi.nlm.nih.gov/pubmed/24984688

Kiviniemi A, Gardberg M, Autio A, Li X-G, Liljenbäck H, Heuser VD, Käkelä M, Sipilä H, Kurkipuro J, Ylä-Herttuala S, Knuuti J, Minn H, Roivainen A. Feasibility of experimental BT4C glioma models for somatostatin receptor 2 targeted therapies. Acta Oncol 53:1125–1134, 2014
http://www.ncbi.nlm.nih.gov/pubmed/24957558

Koski A, Ahtinen H, Liljenbäck H, Roivainen A, Koskela A, Oksanen M, Partanen K, Laasonen L, Kairemo K, Joensuu T, Hemminki A. [18F]-Fluorodeoxyglucose positron emission tomography and computed tomography in response evaluation of oncolytic adenovirus treatments of patients with advanced cancer. Hum Gene Ther 24:1029–1041, 2013
http://www.ncbi.nlm.nih.gov/pubmed/24099555

Autio A, Vainio PJ, Suilamo S, Mali A, Vainio J, Saanijoki T, Noponen T, Ahtinen H, Luoto P, Teräs M, Jalkanen S, Roivainen A. Preclinical evaluation of a radioiodinated fully human antibody for in vivo imaging of vascular adhesion protein-1-positive vasculature in inflammation. J Nucl Med 54:1315–1319, 2013
http://www.ncbi.nlm.nih.gov/pubmed/23847292

Kalliokoski S, Sulic AM, Korponay-Szabó IR, Frias R, Perez MA, Martucciello S, Roivainen A, Pelliniemi LJ, Esposito C, Griffin M, Sblattero D, Mäki M, Kaukinen K, Lindfors K, Caja S. Celiac disease–specific TG2-targeted autoantibodies inhibit angiogenesis ex vivo and in vivo in mice by interfering with endothelial cell dynamics. PLoS One 8:e65887, 2013
http://www.ncbi.nlm.nih.gov/pubmed/23824706

Lankinen P, Lehtimäki K, Hakanen AJ, Roivainen A, Aro HT. A comparative 18F-FDG PET/CT imaging of Staphylococcus aureus and Staphylococcus epidermidis infections in the rabbit tibia. EJNMMI Res 2:41, 2012
http://www.ncbi.nlm.nih.gov/pubmed/22824200

Silvola JMU, Saraste A, Laitinen I, Savisto N, Laine VJO, Heinonen SE, Ylä-Herttuala S, Saukko P, Nuutila P, Roivainen A, Knuuti J. Effects of age, duration of high-fat diet, and type 2 diabetes on the development and 18F-FDG uptake of atherosclerotic plaques in mice. JACC Cardiovasc Imag 4:1294–1301, 2011
http://www.ncbi.nlm.nih.gov/pubmed/22172786

Silvola JMU, Saraste A, Forsback S, Laine JO, Saukko P, Heinonen S, Ylä-Herttula S, Roivainen A, Knuuti J. Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice. Arterioscler Thromb Vasc Biol 31:1011–1015, 2011
http://www.ncbi.nlm.nih.gov/pubmed/21372297

Aalto K, Autio A, Kiss EA, Elima K, Nymalm Y, Veres TZ, Marttila-Ichihara F, Elovaara H, Saanijoki T, Crocker PR, Maksimow M, Bligt E, Salminen TA, Salmi M, Roivainen A, Jalkanen S. Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be utilized in PET-imaging of inflammation and cancer. Blood 118:3725–3733, 2011
http://www.ncbi.nlm.nih.gov/pubmed/21821708

Autio A, Ujula T, Luoto P, Salomäki S, Jalkanen S, Roivainen A. PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein-1 targeting peptide 68Ga-DOTAVAP-P1 – comparison with 18F-FDG. Eur J Nucl Med Mol Imaging 37:1918–1925, 2010 
http://www.ncbi.nlm.nih.gov/pubmed/20523988

Ujula T, Huttunen M, Luoto P, Peräkylä H, Simpura I, Wilson I, Bergman M, Roivainen A. Matrix metalloproteinase 9 targeting peptides – synthesis, 68Ga-labeling and preliminary evaluation in a rat melanoma xenograft model. Bioconjug Chem 21:1612–1621, 2010
http://www.ncbi.nlm.nih.gov/pubmed/20795647