UTU

Zhang F-P, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Korhonen H, Laiho A, Elo L, Ohlsson C, Kotaja N, Poutanen M, Sipilä P, Palvimo J. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction. Nature Communications 2019 Feb 15;10(1):777
https://www.ncbi.nlm.nih.gov/pubmed/30770815

Hakkarainen J, Zhang F-P, Cisneros Montalvo S, Nurmio M, Toppari J, Ohlsson C, Kotaja N, Sipilä P, Poutanen M. Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility. FASEB J. 2018 Jan 24:fj201700921R. doi: 10.1096/fj.201700921R.
https://www.ncbi.nlm.nih.gov/pubmed/29401623

Vehmas AP, Adam M, Laajala TD, Kastenmüller G, Prehn C, Rozman J, Ohlsson C, Fuchs H, Hrabě de Angelis M, Gailus-Durner V, Elo LL, Aittokallio T, Adamski J, Corthals G, Poutanen M, Strauss L. Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse. J Proteomics. 133:66-75, 2016
http://www.ncbi.nlm.nih.gov/pubmed/26691839

Björkgren I, Alvarez L, Blank N, Balbach M, Turunen H, Laajala TD, Toivanen J, Krutskikh A, Wahlberg N, Huhtaniemi I, Poutanen M, Wachten D, Sipilä P. Targeted inactivation of the mouse beta-defensin41 alters sperm flagellar beat pattern and zona pellucida binding. Mol Cell Endocrinol 427:143-54, 2016
http://www.ncbi.nlm.nih.gov/pubmed/26987518

Björkgren I, Gylling H, Turunen H, Huhtaniemi I, Strauss L, Poutanen M, Sipilä P. Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane. FASEB J. Feb;29(2):433-42, 2015
http://www.ncbi.nlm.nih.gov/pubmed/25366345

Turunen HT, Sipilä P, Strauss L, Björkgren I, Huhtaniemi I, Poutanen M. Loss of Bmyc results in increased apoptosis associated with upregulation of Myc expression in juvenile murine testis. Reproduction. Oct;144(4):495-503, 2012
http://www.ncbi.nlm.nih.gov/pubmed/22869780

Björkgren I, Saastamoinen L, Krutskikh A, Huhtaniemi I, Poutanen M, Sipilä P. Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling. PLoS One. 7(6):e38457, 2012
http://www.ncbi.nlm.nih.gov/pubmed/22701646

Turunen HT, Sipilä P, Krutskikh A, Toivanen J, Mankonen H, Hämäläinen V, Björkgren I, Huhtaniemi I, Poutanen M. Loss of cysteine-rich secretory protein 4 (Crisp4) leads to deficiency in sperm-zona pellucida interaction in mice. Biol Reprod. Jan 16;86(1):1-8, 2012
http://www.ncbi.nlm.nih.gov/pubmed/21865554

Adam M, Urbanski H, Garyfallou V, Welsch U, Köhn F, Schwarzer U, Strauss L, Poutanen M, Mauerhofer A.  High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function. Int J Androl. Aug;35(4):550-561, 2012 
http://www.ncbi.nlm.nih.gov/pubmed/22413766