Myeloid cells in regulation of chronic inflammation, autoimmunity and tumor microenvironment

Organization:

University of Turku, Institute of Biomedicine, Kiinamyllynkatu 10, FI-20520 TURKU, Finland

Research group:

Lauri Polari, Ph.D.; Hristo Zlatev, MD; Santeri Anttila B. Med. Karoliina Suominen, B.Sc., Anja Hjelt, B.Sc.

The goal of the project:

In this research project the function of myeloid cells in regulation of immune responses is evaluated. This includes chronic inflammations and autoimmunity as well as the role of tumor associated mac-rophages (TAMs) in maintaining an immunosuppressive status in the tumor microenvironment and promotion of cancer cell migration and invasion. Special emphasis is put on the (exosomal) miRNA communication between different cell populations locally and distally. Further, novel treatment mo-dalities based either on hormone receptor signaling or the pleiotropic effects of bisphosphonate (induced) metabolites are being sought to modulate the function of the myeloid cell population more feasible for the patient.

Selected Publications:

 

Lauri Polari, Anu Wiklund, Sofia Sousa, Lauri Kangas, Tero Linnanen, Pirkko Härkönen, Jorma Määttä (2018) SERMs promote anti-inflammatory signaling and phenotype of CD14+ cells. Inflammation, 41, 1157-1171

Bendre A, Moritz N, Väänänen V, Määttä JA (2018) Dicer1 ablation in osterix positive bone forming cells affects cortical bone homeostasis. Bone, 106, 139-147

Ameya Bendre, Kalman G. Büki and Jorma A. Määttä (2017) Fam3c modulates osteogenic differentiation by down-regulating Runx2, Differentiation, 93, 50-57

Sousa S, Brion R, Lintunen M, Kronqvist P, Sandholm J, Mönkkönen J, Joensuu H, Heymann D, Määttä J. Human breast cancer cells educate macrophages toward the M2 activation status. Breast Cancer Research, 17:101, 2015 

Sousa S, Auriola S, Mönkkönen J, Määttä J. N-BPs skew murine macrophages cultured with soluble factors from breast cancer cells toward M1 phenotype. BMC Cancer, 15:4, 2015

Arkko S, Zlatev HP, Mönkkönen H, Räikkönen J, Bendzaïd I, Clézardin P, Mönkkönen J,  Määttä JA. Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells. Cancer Letters, 357, 279-85, 2015 

Määttä JA, Büki KG, Gu G, Alanne MH, Vääräniemi J, Liljenbäck H, Poutanen M, Härkönen P, Väänänen K. Inactivation of Estrogen Receptor Alpha in Bone Forming Cells Induces Bone Loss in Female Mice. Faseb Journal, 27, 478-488, 2013

Määttä JA, Nieminen-Pihala V, Büki KG, Elo TD, Silvola T, Poutanen M, Härkönen P, Väänänen K. Inactivation of the Androgen Receptor in Bone Forming Cells Leads to Trabecular Bone Loss in Adult Female Mice. BoneKEy Reports 2, Article number: 440, 2013

Principal Investigator:
Jorma Määttä, PhD 
Adjunct Professor of Molecular Cell Biology

Email: jmaatta(at)utu.fi

tel: +358 29 450 4466
+358 50 400 4219