Myeloid cells in regulation of chronic inflammation, autoimmunity and tumor microenvironment
University of Turku, Department of Cell Biology and Anatomy, Kiinamyllynkatu 10, FI-20520 TURKU, Finland
Lauri Polari, Ph.D.; Ameya Bendre, M. Tech; Sofia Sousa, M.Sc.; Hristo Zlatev, MD; Mervi Laanti, B.Sc.
The goal of the project:
In this research project the function of myeloid cells in regulation of immune responses is evaluated. This includes chronic inflammations and autoimmunity as well as the role of tumor associated mac-rophages (TAMs) in maintaining an immunosuppressive status in the tumor microenvironment and promotion of cancer cell migration and invasion. Special emphasis is put on the (exosomal) miRNA communication between different cell populations locally and distally. Further, novel treatment mo-dalities based either on hormone receptor signaling or the pleiotropic effects of bisphosphonate (induced) metabolites are being sought to modulate the function of the myeloid cell population more feasible for the patient.
Sousa S, Brion R, Lintunen M, Kronqvist P, Sandholm J, Mönkkönen J, Joensuu H, Heymann D, Määttä J. Human breast cancer cells educate macrophages toward the M2 activation status. Breast Cancer Research, 17:101, 2015
Sousa S, Auriola S, Mönkkönen J, Määttä J. N-BPs skew murine macrophages cultured with soluble factors from breast cancer cells toward M1 phenotype. BMC Cancer, 15:4, 2015
Arkko S, Zlatev HP, Mönkkönen H, Räikkönen J, Bendzaïd I, Clézardin P, Mönkkönen J, Määttä JA. Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced V9V2 T cell cytotoxicity in PC-3 prostate cancer cells. Cancer Letters, 357, 279-85, 2015
Määttä JA, Büki KG, Gu G, Alanne MH, Vääräniemi J, Liljenbäck H, Poutanen M, Härkönen P, Väänänen K. Inactivation of Estrogen Receptor Alpha in Bone Forming Cells Induces Bone Loss in Female Mice. Faseb Journal, 27, 478-488, 2013
Määttä JA, Nieminen-Pihala V, Büki KG, Elo TD, Silvola T, Poutanen M, Härkönen P, Väänänen K. Inactivation of the Androgen Receptor in Bone Forming Cells Leads to Trabecular Bone Loss in Adult Female Mice. BoneKEy Reports 2, Article number: 440, 2013
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