Pharmacology of α2-adrenoceptor subtypes and hypoxia in heart functions including investigation of lower urinary tract functions

Organization:

Institute of Biomedicine and Faculty of Science and Engineering, Department of Biology, Laboratory of Animal Physiology, University of Turku

Research Group:

Senior Scientists: Mika Scheinin, Prof., Katja Anttila, Associate Prof., Suvi Ruohonen, PhD

Technical personnel: Sanna Tikka, Laboratory Engineer., Katariina Pohjanoksa, MSc

Doctoral thesis student: Luca Pettinau

Graduate student: Tytti Uurasmaa

The goal of the projects:

Our main interest fields are related to investigating cardiovascular functions, i.e. the role of alpha 2-adrenoceptors and hypoxia. Our in vitro methods to test cardiac and vascular functions include isometric micromyography, the Langendorff perfused heart preparation and the Radnoti working heart model. In addition, we are interested in pharmacokinetics of alpha 2-adrenoceptor-related drugs, also receptor subtype-selective ones. including urodynamical sturies in animal models.

Representative publications:

Rinne P, Harjunpää J, Scheinin M, Savontaus E. Blood pressure regulation and cardiac autonomic control in mice overexpressing alpha- and gamma-melanocyte stimulating hormone. Peptides. 2008 Nov;29(11):1943-52

Streng T, Santti R, Andersson KE. Voiding effects mediated by α2-adrenoceptors in the anaesthetized male rat. BJU Int. 2010 Nov;106(10):1546-9

Anttila K, Farrell AP, Patterson DA, Hinch SG & Eliason EJ (2019). Cardiac SERCA activity in sockeye salmon populations: an adaptive response to migration conditions. Can J Fish Aquat Sci 76:1-5

Anttila K, Mauduit F, Le Floch S, Claireaux G & Nikinmaa M (2017). Influence of crude oil exposure on cardiac function and thermal tolerance of juvenile rainbow trout and European seabass. Environ Sci Poll Res 24:19624-19634

Eliason E & Anttila K (2017). Temperature and the Cardiovascular System. In a book: Fish Physiology. Ed. Gamperl AK, Gillis TE, Farrell AP & Brauner CJ. Springer. pp. 235-297

Contact
Tomi Streng, PhD
Adjunct Professor of Animal Physiology

Email: tomi.streng(at)utu.fi

Tomi Streng