Pharmacology of α2-adrenoceptor subtypes

Organization:

Institute of Biomedicine (Department of Pharmacology, Drug Development and Therapeutics), University of Turku

Research Group:

Senior Scientists: Mika Scheinin, Prof., Maria Lahtinen, PhD (CRST)., Saku Ruohonen, PhD., Suvi Ruohonen, PhD

Scientists: Ville Ranta-Panula, MSc (CRST)

Technical personnel: Sanna Tikka, Laboratory Engineer., Katariina Pohjanoksa, MSc

Graduate students: Teemu Kipinoinen

The goal of the project:

Our main interest fields are related to investigating cardiovascular functions, in particular the role of alpha 2-adrenoceptors. We use versatile methodology, which includes in vivo monitoring of blood pressure, heart rate and locomotor activity with radiotelemetry of awake animals. Our in vitro methods to test cardiac and vascular functions include isometric micromyography, the Langendorff perfused heart preparation and the Radnoti working heart model. In addition, we are interested in pharmacokinetics of alpha 2-adrenoceptor-related drugs, also receptor subtype-selective ones. These studies are performed with our automated blood sampling system, which allows stress-free sample collection from freely moving rodents.

Representative publications:

Rinne P, Harjunpää J, Scheinin M, Savontaus E. Blood pressure regulation and cardiac autonomic control in mice overexpressing alpha- and gamma-melanocyte stimulating hormone. Peptides. 2008 Nov;29(11):1943-52

Streng T, Santti R, Andersson KE. Voiding effects mediated by α2-adrenoceptors in the anaesthetized male rat. BJU Int. 2010 Nov;106(10):1546-9

Contact
Tomi Streng, PhD
Adjunct Professor of Animal Physiology

Email: tomi.streng(at)utu.fi

Tomi Streng