The importance of improved statistical methods in preclinical studies was addressed by Sci Transl Med.

The authors (Aittokallio, Scherer, Poutanen, Freedman) within the article (http://stm.sciencemag.org/content/9/389/eaal4101.short  ) emphasize the importance of applying better baseline stratification factors during the preclinical studies to improve the fitness and quality of the models and their translatability to clinical trials. Tools for improving the analyses have also been recently developed by TCDM (https://biomedportal.utu.fi/utu-apps/Rvivo/ ), and scientists are encouraged to apply  these tools to further improve the quality of their studies.