Monitoring of cardiovascular functions constitutes an important part of the phenotypic characterization of an animal model. The same technologies are also employed when cardiovascular variables are used as efficacy or safety endpoints in novel therapeutic interventions.Methods available for cardiovascular studies in rodents include telemetric monitoring of blood pressure and heart rate in awake animals, instrumentation of anesthetized animals and in vitro assessment of cardiac and vascular functions (incl. isometric micromyography, Langendorff perfused heart preparation and Radnoti working heart model). In addition, automated blood sampling with solution for stress free sampling in freely moving rodents is available. Our AccuSampler µ system may be used in drug metabolism and pharmacokinetics, safety pharmacology, toxicology and biomarker studies.

Coordinators
Petteri Rinne, PhD

Email: petteri.rinne(at)utu.fi

 
Tomi Streng, PhD
Adjunct Professor of Animal Physiology

Email: tomi.streng(at)utu.fi

Cardiovascular Research