TCDM provides techniques for generating genetically modified mice in an effective manner, and technical support and collaboration is provided in all phases of the project. This includes all necessary steps for GM mouse production from construct design to the breeding of founder mice or chimeric mice. TCDM provides expertise in mouse colony handling, experimental surgery on mice, embryo cryopreservation/recovery and conversion of mouse lines to specific pathogen free status. We also hold several reporter mice and Cre mice at the facility.