Hypertension – induced models

Diet high in NaCl content (high-salt diet) is used to induce hypertension in mice.

DOCA-salt induced hypertension combines deoxycorticosterone acetate and high salt intake to induce high blood pressure.

Rinne P et al Genetic and pharmacologic mouse models of chronic melanocortin activation show enhanced baroreflex control of heart rate. Regul Pept. 182:19-27, 2013

Rinne P et al α-MSH Analogue Attenuates Blood Pressure Elevation in DOCA-Salt Hypertensive Mice. PLoS One 8(8):e72857, 2013.

Impaired vascular function

Diets high in fat (diet induced obesity) or salt (diet induced hypertension) impair endothelial function, which is evidenced using vascular function analysis by wire myography.

Rinne P et al α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction. Cardiovasc Res. 97:360-368, 2013