Intestinal inflammation and colorectal cancer
TCDM offers multidisciplinary know-how and research services related to studying established mouse models of principal human intestinal disorders including colitis (colonic inflammation, inflammatory bowel diseases) and colon cancer. The unit offers design of experiments including know-how on intestine-related analysis methodology, isolation techniques of intestinal epithelial cells and growth of organoids (min-gut). Intestinal Diseases Unit
Colorectal cancer and colitis: Misiorek JO et al, Carcinogenesis 37:777, 2016.
Colitis: Lähdeniemi IAK et al, Cell Death Diff., 24:984, 2017. Helenius TO et al, Cells 5, Pii E35, 2016. Asghar et al, Am J Physiol Gastrointest Liver Physiol, 310:G1147, 2106. Helenius TO et al, Mol. Biol. Cell 26:2298, 2015. Asghar MN et al, PLOS One 10, e0127436. Habtezion A et al. Proc Natl Acad Sci USA, 108:1445-1450, 2011. Toivola DM et al. J Cell Biol, 164:911-921, 2004. Habtezion A, et al. J Cell Sci, 118:1971-1980, 2005.
Imaging of colitis: Asghar MN et al, Inflam. Bowel Dis. 20, 1435, 2014.
Nanomaterial targeting to intestine: Desai D et al, Int J. Nanomedicine 11: 299, 2016.